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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Small molecule drug conjugate ： ウィキペディア英語版 Small molecule drug conjugate Small molecule drug conjugates or SMDCs are built with three modules: a targeting ligand, a linker and a drug payload. The targeting ligands consist of low molecular weight, high-affinity ligands that are precisely linked to potent drugs. The linkers are designed to be stable in the bloodstream and then release the active drug from the targeting ligand when the SMDC is taken up by the diseased cell. The drug payloads are highly active molecules that are too toxic to be administered in their untargeted forms at therapeutic dose levels. This modular approach allows varying targeting ligands, linker systems and drug payloads and generate SMDCs for different diseases.〔http://www.radiologytoday.net/archive/rt0213p12.shtml〕 The most advanced SMDC is vintafolide, a derivative of the anti-mitotic chemotherapy drug vinblastine which is chemically linked to folic acid.〔http://www.radiologytoday.net/archive/rt0213p12.shtml〕 SMDCs are currently being developed by Endocyte for treating cancer, inflammatory diseases and kidney disease, as well as a companion imaging agent that is created by replacing the potent drug with an imaging agent.〔http://www.ddn-news.com/index.php?pg=77&articleid=6278〕〔http://www.radiologytoday.net/archive/rt0213p12.shtml〕 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Small molecule drug conjugate」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.